Fast forward to now, the present day, and the year ETM 12 will be held. From all over Japan, Eto-shin candidates, or in other words, Eto-musumes gather in great numbers.
Within that group exists a single cat Eto-musume.
Her name is Nya-tan. She is thought of as the one closest to becoming an Eto-shin, but is a misfortunate girl who always ends up undermined by evil rodents.
The only way to become the 12 zodiac signs is to beat all the Eto-shins. However, the power of the Eto-shins is so great, and no Eto-musume has ever won in the tournament for the past two thousand years.
When Nya-tan meets an ordinary high school boy, Takeru Amato, the story begins!